R&D capabilities and services
The main R&D Center, located in Barcelona, contains several Synthesis and Analysis Labs, but also a Kilolab (up to 30 L glass reactors) and two Pilot Plants (up to 600 L reactors; total reaction volume: 3 m3). On the other hand, it is worth mentioning the hydrogenation laboratory (up to 5L, 50 bars), where high pressure reactions are developed and optimized, and the High Potent API lab, where development of this kind of compounds is done (up to 1 microg/m³).
The R&D Center in China, contains also a hydrogenation lab (up to 2L; 10 bar) and a Klab (up to 30L).
New technologies are also developed in our labs in order to improve the control of the processes and to reduce the analysis time in the QC labs. Techniques such as XRF, benchtop NMR and PAR probes (NIR, Raman, FBRM, Microscopy, Particle Size, Turbidity...) are being developed to be used in the processes. New manufacturing approaches such as flow chemistry, biocatalysis and process and solid engineering are also developed. Other capabilities are: process safety studies and impurity tracking and structural elucidation (HPLC_2D- QTof).
Analytical methods development by QbD approach using specialized software can be done, giving a great knowledge of the methods and flexibility in terms of easy change implementation and adaptation along the process evolution.
We can help our customers to select and justify the regulatory starting materials, design the impurity control strategy of the whole process and perform the PMIs assessment of the process including the nitrosamines assessment. These activities ensure our clients that the safety of the process is guaranteed and patients will be protected.